Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats

Background and Aims: The study was designed to evaluate the anti-fertility effect of methanolic extract Clerodendrum serratum (MECS) on mature male rats. Methods: vehicles MECS were administered orally four groups forty albino rats consecutive days for 30 days. At end experimental period, five animals from both control given anesthesia animal reproductive organs collected evaluated by studying following parameters (i) Body organ weight (ii) Biochemical estimation (iii) Reproductive hormone analysis (iv) Abnormalities in histology. Another each group subjected fertility testing. Results: This shows that female which mated with treated delivered fewer pups than those An antisteroidogenic revealed through increased concentration testicular cholesterol ascorbic acid However, Δ5 -3β-hydroxysteroid dehydrogenase (Δ5 -3β-HSD), glucose-6-phosphate (G-6-PD); serum hormones testosterone, FSH LH significantly reduced. Conclusion: present investigation discovered MECS, confirms antifertility this plant. encourages traditional use plant Indian subcontinent as a contraceptive.